SINOMENINE PROTECTS AGAINST MORPHINE DEPENDENCE THROUGH THE NMDAR1/CAMKII/CREB PATHWAY: A POSSIBLE ROLE OF ASTROCYTE-DERIVED EXOSOMES

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood.Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes in central nervous system diseases.However, the effect of pommel sack sinomenine on astrocyte-derived exosomes for the amelioration of mor

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What is Wrong with Populism?

The main goal of this article is to explore the relationship between populism and representative democracy.The paper is divided into two parts.In the first part, the paper offers a detailed analysis of the three criticisms of populism and the implications these criticisms have on our understanding of representative democracy.First, it addresses the

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Necrotising Myositis, the Deadly Impersonator

We report two cases of patients with necrotising myositis who presented initially with limb pain and swelling on a background of respiratory complaints.Patient 1, a previously well 38-year-old female, underwent Leg Extension Cable various investigations in the emergency department for excessive lower limb pain and a skin rash.Patient 2, a 61-year-o

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Convergent and divergent patterns of morphological differentiation provide more evidence for reproductive character displacement in a wood cricket Gryllus fultoni (Orthoptera: Gryllidae)

Abstract Background In ecological character displacement, traits involved in reproductive isolation may not evolve in arbitrary directions when changes in these traits are by-products of adaptation to an ecological niche.In reproductive character displacement, however, selection acts directly on reproductive characters to enhance the degree of repr

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