Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes
Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood.Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes in central nervous system diseases.However, the effect of pommel sack sinomenine on astrocyte-derived exosomes for the amelioration of mor